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• Melatonin is marketed to help promote total sleep time, aid with fatigue from jet lag, or balance circadian rhythms from jet lag and rotating shift work. Evidence suggests melatonin may reduce the time it takes for people with delayed sleep phase syndrome (i.e., sleep is delayed by two or more hours beyond the conventional bedtime, causing difficulty in waking at a desired time) to fall asleep. Melatonin may also help re-set the body?s sleep-wake cycle.
• There are a number of studies that suggest a relationship between decline of melatonin function and the symptoms of dementia. Meta-analysis was conducted on data from three randomized, placebo controlled trials that were designed to evaluate melatonin for managing dementia-related cognitive changes; data also were pooled from two of these trials that evaluated melatonin for managing mood and behavioral disturbances. Significantly improved outcomes were found from the meta-analysis of psychopat
• Melatonin has been shown to serve as a mediator between the thermoregulatory and arousal system in humans, such that exogenous administration of melatonin during the day can result in sleepiness in association with reduced core temperature.
• Melatonin increased sleep efficiency in people with a secondary sleep disorder.
• Melatonin significantly increased total sleep time in people suffering from sleep restriction.

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